Promoting crystallization by increasing and enhancing intermolecular interactions

Regulation of Rhogef Activity by Intramolecular and Intermolecular Sh3 Interactions

INTERMOLECULAR SH3 INTERACTIONS Martin R. Schiller, Kausik Chakrabarti, Glenn F. King, Noraisha I. Schiller, Betty A. Eipper, and Mark W. Maciejewski From the University of Connecticut Health Center, Departments of Neuroscience, Molecular, Microbial, and Structural Biology, and Center for Structural Biology Running Title: Regulation of GEF activity by SH3 domains Address correspondence to Marti...

Intermolecular Interactions and Protein Dynamics by Solid‐State NMR Spectroscopy

Understanding the dynamics of interacting proteins is a crucial step toward describing many biophysical processes. Here we investigate the backbone dynamics for protein GB1 in two different assemblies: crystalline GB1 and the precipitated GB1-antibody complex with a molecular weight of more than 300 kDa. We perform these measurements on samples containing as little as eight nanomoles of GB1. Fr...

Bifurcation and Chaos in Size-Dependent NEMS Considering Surface Energy Effect and Intermolecular Interactions

The impetus of this study is to investigate the chaotic behavior of a size-dependent nano-beam with double-sided electrostatic actuation, incorporating surface energy effect and intermolecular interactions. The geometrically nonlinear beam model is based on Euler-Bernoulli beam assumption. The influence of the small-scale and the surface energy effect are modeled by implementing the consistent ...

Increasing Energy Efficiency by Reducing Losses and Promoting Value Propositions

Promoting melanoma growth and metastasis by enhancing VEGF expression

Angiogenesis plays an essential role in tumor growth and metastasis and is a promising target for cancer therapy. Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis. The present study was designed to determine the role of VEGF in tumor growth and metastasis. The sequences for the VEGF gene were cloned into expression plasmids and then transfected into melanoma B16 cell...